It's expected to become a Category 1 hurricane Friday as it approaches the Dominican Republic and Haiti.
As coastal residents prepare, forecasters say Isaac will likely weaken a little while crossing over Haiti and the eastern two-thirds of Cuba.
It's then expected to move toward Florida, but experts say there's "significant uncertainty" about the threat it poses to that state.
Seventy-thousand delegates, journalists and protesters are expected to descend on Tampa for next week's Republican National Convention.
Meanwhile, Mississippi Governor Phil Bryant attended a 3 o'clock meeting Thursday afternoon at MEMA headquarters.
Bryant said, "We'll begin the process. We'll be in contact with emergency managers on the three coast counties and slowly beginning the process of planning to see if implementation will be necessary."
Out in the Eastern Atlantic, another tropical storm, Joyce, formed over the open water, but forecasters say it poses no immediate threat to land.
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