The Mississippi Highway Patrol has responded to Highway 16 near Sharon Road in Madison County for an accident between a tractor trailer and an SUV.
MHP reports the truck and a Chevrolet Tahoe collided in the westbound lane.
One adult and three minors inside the Tahoe have been taken to a hospital with injuries.
The truck driver was not injured.
As of 8:45 Wednesday morning, Highway 16 was blocked off in that area.
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